BC-1258|CAS 1507370-40-2|DC Chemicals

Cas No.:	1507370-40-2
Chemical Name:	N,N'-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine
Synonyms:	BC-1258;BC 1258;BC1258
SMILES:	C(CNCC1C=CC(C2SC=CN=2)=CC=1)NCC1C=CC(C2SC=CN=2)=CC=1
Formula:	C₂₂H₂₂N₄S₂
M.Wt:	406.57
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].
Target:	FBXL2[1]
In Vivo:	BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice[1].
References:	[1]. Chen BB, et, al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis. Cell Death Dis. 2013 Aug 8;4(8):e759.

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