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BC-1258

  Cat. No.:  DC43054   Featured
Chemical Structure
1507370-40-2
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More than 5000 active chemicals with high quality for research!
Field of application
Unique F-box/LRR-repeat protein 2 (FBXL2) activator
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1507370-40-2
Chemical Name: N,N'-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine
Synonyms: BC-1258;BC 1258;BC1258
SMILES: C(CNCC1C=CC(C2SC=CN=2)=CC=1)NCC1C=CC(C2SC=CN=2)=CC=1
Formula: C22H22N4S2
M.Wt: 406.57
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].
Target: FBXL2[1]
In Vivo: BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice[1].
References: [1]. Chen BB, et, al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis. Cell Death Dis. 2013 Aug 8;4(8):e759.
MSDS
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MSDS_26680_DC43054_1507370-40-2
COA
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