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| Cas No.: | 1345858-76-5 |
| Chemical Name: | CID-49835928 ML-248 |
| Synonyms: | CID49835928 ML-248 ML-248 ML-248;CID 49835928;CID-49835928;CYM50308;CYM-50308;CYM 50308 |
| SMILES: | FC1C=CC(N2C(C)=C(/C=C3/C(=O)N(C)/C(=N/CCOC)/S/3)C=C2C)=C(F)C=1 |
| Formula: | C20H21F2N3O2S |
| M.Wt: | 405.461450338364 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | CYM50308 is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM[1]. |
| Target: | EC50: 56 nM (S1P4-R), 2100 nM (S1P5-R)[1] |
| In Vitro: | The disclosed lead molecule CYM50308 (Compound 24f) displays low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P-Rs subtypes. Noteworthy, CYM50308 provides a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the in vivo receptor function[1]. |
| References: | [1]. Urbano M, et al. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6739-45. |
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| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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