Natural DnaE1 blocker, inducing a DNA damage response in Mycobacterium tuberculosis (Mtb) and inhibiting growth by blocking the replicative DNA polymerase, DnaE1

Activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4

Inhibitor of extrinsic and intrinsic thrombin generation, inhibiting clot-bound and free (fluid-phase thrombin)

Antagonist of alpha-2 adrenergic receptors and inhibitor of the neuronal uptake of norepinephrine

Novel Gut-Restricted Inhibitor of Intestinal Sodium-Dependent Phosphate Transport Protein 2b (NaPi2b) for the Treatment of Hyperphosphatemia

Triple reuptake inhibitor

Novel repeat-structure-specific DNA ligand, specifically binding slipped-CAG DNA intermediates of expansion mutations

Novel fluorescent probe for detection of endogenously produced Naph-O2˙– in living cells and tissues

Mixed agonist/antagonist opioid modulator, binding with high affinity to the MOR and KOR, and having relatively low affinity for the DOR

Novel highly selective antibacterial agent against Propionibacterium acnes

Novel potent full agonist for orexin receptor

Partial estrogen antagonist, inhibiting angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF), inducing oxidative stress, protein kinase C and calcium signaling

Electron donor and cofactor for many redox enzymes including nitric oxide synthetase

Coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage

Novel antiviral agent against the replication of influenza virus A/H3N2 subtype in Madin-Darby canine kidney (MDCK) cells

Derivative of loline

Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) combination for the treatment of multiple sclerosis (MS)-related moderate to severe spasticity

Alkylating agent, forming DNA adducts at the C-8 position in guanine, resulting in single strand breaks, demonstrating carcinogenic action

Deuterium labeled m6A used in important m6A physiological pathways related studies

Novel RNA labeling probe through both metabolic and enzyme-assisted manners

Glucokinase activator (GKA)

Competitive inhibitor of both SPHK1 and SPHK2

Novel potent and selective PROTAC degrader of BRD3/4

Bacterial RNA polymerase (RNAP) inhibitor

Inhibitor of the chaperonin activity of HSP60, correlating to LONP and LRP130 aggregation

Novel inducer of apoptosis in a Myc-dependent manner, inhibiting Myc-driven transformation and disrupting MYC-Max interaction

Novel potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V

Myotoxin II fragment

Novel inhibitor of zinc finger DHHC domain-containing (zDHHC) enzymes

Novel inhibitor of the protein-protein interactions between the bHLHZip proteins c-Myc and Max