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AZD-5672

  Cat. No.:  DC48046   Featured
Chemical Structure
780750-65-4
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More than 5000 active chemicals with high quality for research!
Field of application
AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). AZD-5672 shows moderate activity against the hERG ion channel (binding IC50=7.3 μM). AZD5672 is a substrate of human P-gp, and inhibits P-gp-mediated digoxin transport (IC50=32 μM). AZD-5672 can be used for the research of rheumatoid arthritis.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 780750-65-4
Chemical Name: Azd-5672
Synonyms: 61XQN688TW;(R)-N-(1-(3-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)propyl)piperidin-4-yl)-N-ethyl-2-(4-(methylsulfonyl)phenyl)acetamide;BDBM50185666;DB11804;Benzeneacetamide, N-(1-((3R)-3-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)propyl)-4-piperidinyl)-N-ethyl-4-(methylsulfonyl)-;Q27263396;Benzeneacetamide, N-ethyl-4-(methylsulfonyl)-N-[1-[(3S)-3-[4-(methylsulfonyl)phenyl]-3-(3,5-difluorophenyl)propyl]-4-piper;Azd-5672;Benzeneacetamide, N-ethyl-4-(methylsulfonyl)-N-[1-[(3S)-3-[4-(methylsulfonyl)phenyl]-3-(3,5-;AZD-5672;AC-31377;NS00072177;MS-30870;780750-65-4;HY-119101;CHEMBL212689;N-[1-[(3R)-3-(3,5-difluorophenyl)-3-(4-methylsulfonylphenyl)propyl]-4-piperidyl]-N-ethyl-2-(4-methylsulfonylphenyl)acetamide;DA-50857;EX-A5833;N-(1-((3R)-3-(3,5-difluorophenyl)-3-(4-methanesulfonylphenyl)propyl)piperidin-4-yl)-N-ethyl-2-(4-methanesulfonylphenyl)acetamide;Benzeneacetamide, N-ethyl-4-(methylsulfonyl)-N-[1-[(3S)-3-[4-(methylsulfonyl)phenyl]-3-(3,5-difluorophenyl)propyl]-4-piperidinyl]-;SCHEMBL18840905;G17381;UNII-61XQN688TW;N-{1-[(3R)-3-(3,5-difluorophenyl)-3-(4-methanesulfonylphenyl)propyl]piperidin-4-yl}-N-ethyl-2-(4-methanesulfonylphenyl)acetamide;CS-0068004;AKOS040750676
SMILES: S(C)(C1C=CC(=CC=1)[C@H](C1C=C(C=C(C=1)F)F)CCN1CCC(CC1)N(C(CC1C=CC(=CC=1)S(C)(=O)=O)=O)CC)(=O)=O
Formula: C32H38F2N2O5S2
M.Wt: 632.781333446503
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC70292 CCR4-IN-38 CCR4-IN-38 (CCR4-351) is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 50 nM (Chemotaxis inhibition).CCR4-IN-38 inhibits the recruitment of Treg into the tumor microenvironment (TME).CCR4-IN-38 elicits antitumor responses as a single agent or in combination with an immune checkpoint blockade.
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