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CFT8634

  Cat. No.:  DC70304   Featured
Chemical Structure
2704617-93-4
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More than 5000 active chemicals with high quality for research!
Field of application
CFT-8634 (CFT8634) is a potent, selective, orally bioavailable BRD9 BiDAC degrader with DC50 of 3 nM, high selectivity over BRD4 abd BRD7.Unlike BRD9 inhibition, BRD9 degradation is efficacious in preclinical models of synovial sarcoma and CFT8634 is ongoing for the treatment of SMARCB1-perturbed cancers.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2704617-93-4
Chemical Name: CFT8634
Synonyms: 2,6-Piperidinedione, 3-[[4-[4-[1-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-3,3-difluoro-4-piperidinyl]-1-piperazinyl]-3-fluorophenyl]amino]-;3-[[4-[4-[1-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-3,3-difluoro-4-piperidinyl]-1-piperazinyl]-3-fl2,6-Piperidinedione,
SMILES: N1C(=O)CCC(NC2=CC=C(N3CCN(C4CCN(CC5=C(OC)C=C(C6C(C)=C(C)C(=O)N(C)C=6)C=C5OC)CC4(F)F)CC3)C(F)=C2)C1=O
Formula: C37H45F3N6O5
M.Wt: 710.785619497299
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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