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G6PD activator AG1

  Cat. No.:  DC12438   Featured
Chemical Structure
421581-52-4
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More than 5000 active chemicals with high quality for research!
Field of application
G6PD activator AG1 (AG1) is a specific, small molecule that increases the activity of the wild-type, Canton mutant (R459L, EC50=3 uM) and several other common G6PD mutants; displays no effect on the dimerization or activity of several other NAD- or NADP+-dependent dimeric or tetrameric enzymes, including 6PGD, GAPDH, ALDH2, and ALDH3A1; attenuates ROS-induced pericardial edema in a G6PD-dependent manner in zebrafish, reduces hemolysis of human erythrocytes
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 421581-52-4
Chemical Name: 2,2'-disulfanediylbis(N-(2-(1H-indol-3-yl)ethyl)ethan-1-amine)
Synonyms: AG1;AG-1,AG 1
SMILES: S(CCNCCC1C2=C(NC=1)C=CC=C2)SCCNCCC1C2=C(NC=1)C=CC=C2
Formula: C24H30N4S2
M.Wt: 438.652
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Hwang S, et al. Nat Commun. 2018 Oct 2;9(1):4045.
Description: G6PD activator AG1 is a glucose-6-phosphate dehydrogenase (G6PD) activator with an EC50 of 3 µΜ, extracted from patent WO2019023264A1, compound AG1[1].
Target: IC50: 3 µΜ (G6PD)[1]
References: [1]. https://patents.google.com/patent/WO2019023264A1/en?oq=WO2019023264A1
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
2018-0101
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