Desmosterol is an endogenous agonist of RORgamma; Intermediate in the synthesis of cholesterol.

Rauwolscine hydrochloride is an alpha2-Adrenergic antagonist and partial agonist at 5-HT1A receptors.

Sulfidefluor-7 AM is a novel hydrogen sulphide (H2S) fluorescent probe.

Fenirofibrate is a metabolite of Fenofibrate.

LP117 is a novel drug-specific modulator of ABCB1-mediated drug transport.

Periciazine is a drug that belongs to the phenothiazine class of typical antipsychotics. Periciazine is used to treat short-term severe anxiety or tension and in the maintenance treatment of psychotic disorders such as schizophrenia.

Pencycuron, also known as Monceren, is a phenylurea fungicide.

PD-198306 is a cell-permeable amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC50 = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk's, and PI 3-Kγ (IC50 >1.0 μM).

NCL00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor.

PD-176252 is a non-peptide gastrin-releasing peptide receptor (GRP-R, BB2) and neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 0.17 and 1.0 nM for BB1 and BB2 respectively). It inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM).

TrxR-IN-D9, also known as D9, is a novel inhibitor of thioredoxin reductase (TrxR).

Tiaprost is a prostaglandin F2 alpha analogue as an estrus-synchronizing agent.

NB-64 is a novel human immunodeficiency virus type 1 (HIV-1) entry inhibitor, interferring with the gp41 six-helix bundle formation and blocking virus fusion.

Nitrocefin is an antibiotic, being sensitive to hydrolysis by all lactamases produced by gram-positive and gram-negative bacteria.

Oxantel is a fumarate reductase inhibitor; Anthelmintic.

(S)-alpha-Fluoromethylhistidine HCl is a potent irreversible histidine decarboxylase (HDC) inhibitor and glutathione S-transferase inhibitor. a-FMH was demonstrated to be an effective inhibitor of GST at micromolar concentration, suggesting that off-target effects of a-FMH may limit physiological drug metabolism and elimination by GST-dependent mechanisms.

PD 135158 is a Selective cholecystokinin type B (CCKB)/gastrin receptor agonist. In studies, PD- 135158 stimulates lipase release from isolated rat pancreatic acini dose dependently in a biphasic manner, with identical efficacy but lower potency compared to cholecystokinin octapeptide (CCK-8). PD 135158 is classified into Anti-Anxiety Agents, Central Nervous System Agents, Central Nervous System Depressants, Psychotropic Drugs, and Tranquilizing Agents.

PD 109488 is a metabolite of quinapril. PD 109488, otherwise known as Quinapril Diketopiperazine, is a derivative of Quinapril that acts as an ACE inhibitor. Inhibition of ACE prevents the conversion of signaling peptide angiotensin I into angiotensin II, which acts as a potent vasoconstrictor. Reduced levels of angiotensin II also reduces the amount of aldosterone that is expressed due to RAAS signaling.

Papaverine Hydrochloride, USP, is the hydrochloride of an alkaloid obtained from opium or prepared synthetically. It belongs to the benzylisoquinoline group of alkaloids. It does not contain a phenanthrene group as do morphine and codeine. The most characteristic effect of papaverine is relaxation of the tonus of all smooth muscle, especially when it has been spasmodically contracted. Papaverine Hydrochloride apparently acts directly on the muscle itself. This relaxation is noted in the vascular system and bronchial musculature and in the gastrointestinal, biliary and urinary tracts.

Oxfenicine, also known as UK-25842, is a carnitine palmitoyltransferase I (CPT-1) inhibitor involved in fatty acid metabolism in the heart. In animal studies oxfenicine acts as a cardioprotective agent during ischemia. Oxfenicine produces changes in myocardial substrate utilisation and is attributed to the protection of ischemic stressed myocardium by shifting the cardiac metabolism with reduction of FFA (Free Fatty Acid) utilisation. This may be favourable in circumstances with limited oxygen supply.

Oxantel Pamoate is an anthelmintic used to treat Trichuris trichiura infection.

MR2034 is a kappa-Opioid receptor agonist, stimulating hypothalamic-pituitary-adrenal axis.

MNI-caged-L-Glutamate is a photo sensitive probe, releasing glutamate when photolysed with wavelength between 300 - 380 nm.

Omigapil maleate is a drug that was developed by Novartis and tested in clinical trials for its ability to help treat Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). The development for PD and ALS have been terminated due to lack of benefit, but Santhera Pharmaceuticals bought the compound for development for the treatment of congenital muscular dystrophy (CMD).

Olaquindox is used in prevention of swine dysentary. It is also a growth promoting additive in pig feed.

Nitromifene Citrate A non-steroidal estrogen antagonist (as the 1:1 citrate) most commonly used as a research tool in animal studies.

Netropsin is a basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research. Netropsin is a polyamide with antibiotic and antiviral activity. It has been shown that Netropsin is active both against Gram-positive bacteria and Gram-negative bacteria.

NBI-27914 is a Corticotropin-Releasing Factor Antagonist of the CRF1 and CRF2 recepetors (Corticotropin-releasing factor).

Naxagolide is a sustained release formulation of a naphthoxazine compound with selective D-2 dopamine receptor agonism. It is a dopamine agonist and an Antiparkinsonian.

Navuridine, also known as 3’-Azido-2’,3’-dideoxyuridine, is a dideoxyuridine inhibitor of HIV reverse transcriptase that is related to zidovudine. Navuridine exhibits a relatively short half-life and incomplete oral bioavailability and has not been developed into a clinical drug.