Triclabendazole is an anthelmintic and fasciolicidal, binding to beta-tubulin and preventing the polymerization of the microtubules of which they are part. Studies in vitro and/or in infected animals suggest that triclabendazole and its active metabolites (sulfoxide and sulfone) are absorbed by the tegument of the immature and mature worms, leading to a decrease of the resting membrane potential, inhibition of tubulin function as well as protein and enzyme synthesis. These metabolic disturbances are associated with inhibition of motility, disruption of the surface as well as ultrastructure that includes inhibition of spermatogenesis and vitelline cells.

SB 224289 is a selective 5-HT1B receptor antagonist (pKi = 8.2). SB 224289 displays > 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. SB 224289 is a centrally active following oral administration in vivo.

Suprafenacine is a novel cell permeable selective inhibitor of cancer cell proliferation, binding microtubules at the colchicine-binding site and inhibiting polymerization, leading to G2/M cell cycle arrest and cell death via a mitochondria-mediated apoptotic pathway.

TBMP is a novel inhibitor of the viral envelope protein hemagglutinin (HA)-mediated entry.

Ro 24-7429 is a Tat antagonist. Ro 24-7429 blocks the action of the HIV tat protein and is an analog of Ro 5-3335.

Aminotadalafil is an analog of Tadalafil as a phosphodiesterase type 5 (PDE-5) inhibitor.

2-DG is an inhibitor of glycolysis via its actions on hexokinase, the rate limiting step of glycolysis.

Cyclo-L-Trp-L-Trp is a broad spectrum antifungal, inducing a high degree of acetylation of histones.

FSB is a highly fluorescent amyloid-specific dye.

Quinaprilat is the active metabolite of quinapril, an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and congestive heart failure.

Propranolol Hydrochloride is a non-cardioselective beta-adrenergic antagonist. It has been shown to be active against disorders including cardiac infarcations, arrhythmias, hypertension, and hyperthyroidism.

Talniflumate is a novel potent and selective inhibitor of core mucin-synthesizing enzyme GCNT3 (core 2b-1,6 N-acetylglucosaminyltrans-ferase).

Pyrazoloacridine is an investigational nucleic acid binding agent that inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine was a phase II clinical study to determine the efficacy and toxicities of PZA in patients with metastatic breast cancer (MBC)Pyrazoloacridine appears to intercalate into DNA and inhibit RNA synthesis, DNA synthesis, and the activities of topoisomerases I and II, thereby causing cytotoxicity.

Danofloxacin is a fluoroquinolone antibiotic used in veterinary medicine.

Propoxur is a carbamate insecticide. Propoxur is a non-systemic insecticide with a fast knockdown and long residual effect used against turf, forestry, and household pests and fleas.

Propanidid, also known as Sombrevin, is a short-acting phenylacetate general anesthetic.

Procaterol is an intermediate-acting β2 adrenoreceptor agonist used for the treatment of asthma.

H2DCFDA is a fluorescent cell permeabl ROS indicator.

PNU-142633 selective, high affinity 5-HT1D receptor antagonist and is an experimental drug candidate for the treatment of migraine.

Fenpyroximate is an acaricide and insecticide, blocking the mitochondrial electron transport in complex I.

rac-CCT-250863 is a potent Nek2 inhibitor. exhibiting selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.

HHQ is an antagonist of PqsR.

Sulfaclozine is an antiprotozoal.

Piromidic acid is antibacterial against mainly gram negative organisms. It is used for urinary tract and intestinal infections.

Physostigmine salicylate is a reversible cholinesterase inhibitor, a parasympathomimetic alkaloid. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.

PDP-EA is an FAAH activator, enhancing amidohydrolase activity of FAAH.

Levoglucosenone is a cytotoxic, against human hepatocarcinoma cell lines.

PBI-51 is a competitive Inhibitor of Abscisic Acid-Regulated Gene Expression.

Propachlor is a specific ALDH1A1 inhibitor. It is sometimes used as an herbicide.

L-670596 is a potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist, also showing ALDH1A1 specific inhibitory activity.