Novel partial inhibitor of amphetamine-induced dopamine release

DAT modulator, being unique in affecting substrate uptake without impacting efflux

Human norepinephrine transporter blocker

Natural inhibitor of the Kv1.3 channels in a concentration-dependent manner

Inhibitor of constitutive and inducible STAT3 activation through the activation of SHP-2 tyrosine phosphatase

Natural analgesic, antipyretic, anti-inflammatory, and anti-tumor agent

A2A adenosine receptor agonist

Novel, selective and orally bioavailable c-Met inhibitor, exhibiting antitumor activity both in vitro and in vivo

Novel potent and selective allosteric modulator of sigma-1 receptor

Unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue, effectively reducing GH secretion in human GH-secreting pituitary adenomas even in Octreotide non-responsive tumours.

Novel long-acting, reversible albumin-binding growth hormone (GH) derivative for treatment of growth hormone dificiency

Novel oral, broad-spectrum matrix metalloproteinase inhibitor (MMPI), being >10-fold more active than marimastat in inhibiting the processing of cell-bound TNF-alpha

Natural tumor antagonistic steroidal alkaloid, inducing typical cellular apoptotic hallmarks and cell cycle blockage at S-G2/M phase, activating nuclear import of DFF-40 mediated nucleosomal disruption and cell demise

Narcolepsy agent, being used to treat catalepse and daytime sleepiness in patients with narcolepsy

Hepatoprotective and choleretic agent

PPARdelta receptor agonist

Novel potent inhibitor of SOD1-Derlin-1 interaction

Novel potent inhibitor of SOD1-Derlin-1 interaction

Orally available active prodrug of ICRF-154, interferring with topoisomerase II activity prior to the formation of intermediate cleavable DNA-enzyme complexes during the catalytic cycle resulting in tumor cell growth inhibition

Inhibitor of tubulin polymerization, resulting in cell cycle arrest and induction of apoptosis

Novel macrophage modulator, inhibiting inflammation and M1 polarization of macrophages, restoring the balance between M1-polarized and M2-polarized macrophages in high fat diets (HFD)-induced obese mice resulting in the improvement of adipose inflammation

Highly selective inhibitor of CDK8 and its isoform CDK19

Novel agonist of PPAR-gamma, inhibiting lipopolysaccharide (LPS)-induced NO production and pro-inflammatory cytokines, potentiating interleukin-4-induced arginase-1 expression, promoting microglial polarization toward to an M2 anti-inflammatory phenotype

Inducer of apoptosis in neuroblastoma cells through inhibition of AKT signaling pathway

Novel potent serotonin and noradrenaline reuptake inhibitor (SNRI) with moderate 5-HT2A antagonist activity for anti-depression

Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Eraser (SNIPER), acting as a a protein degradation inducer of phosphodiesterase-4 (PDE4)

Novel potent and selective degrader of the ERα protein

Novel potent degrader of the mitochondrial CRABP-II protein

Novel fused proteins degrader of the His-tagged CRABP-II and Smad2 in cells

Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Eraser (SNIPER), acting as a a protein degradation inducer of bromodomain-containing protein 4 (BRD4)