LY2780301 |CAS 1226801-23-5|DC Chemicals

Cas No.:	1226801-23-5
Chemical Name:	GLXC-26326
Synonyms:	LY2780301;GLXC26326;EX-A7418;example 45 [WO2010056563A1];1226801-23-5;4-(4-(1-(2-(Dimethylamino)ethyl)-4-(4-fluoro-3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperidin-1-yl)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one;SCHEMBL2062874;LY-2780301;GLXC-26326;4-{4-[1-(2-dimethylamino-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1h-imidazol-2-yl]piperidin-1-yl}-5,7-dihydro-pyrrolo[2,3-d]-pyrimidin-6-one;GTPL12617;6H-Pyrrolo[2,3-d]pyrimidin-6-one, 4-[4-[1-[2-(dimethylamino)ethyl]-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl]-1-piperidinyl]-5,7-dihydro-;AKT-IN-23;AKT-IN-23;AKT-IN-23;CS-1100202;CS-1100202;CS-1100202;HY-161704;HY-161704;HY-161704
SMILES:	FC1C=CC(=CC=1C(F)(F)F)C1=CN(CCN(C)C)C(C2CCN(C3C4=C(N=CN=3)NC(C4)=O)CC2)=N1
Formula:	C₂₅H₂₇F₄N₇O
M.Wt:	517.521798372269
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, highly selective, ATP-competitive dual inhibitor of p70S6K and Akt under development for the treatment of solid tumours and non-Hodgkin's lymphoma; drastically decreases proliferation of hMECs with ErbB2-induced p70S6K activation via Cyclin B1 inhibition and cell cycle blockade at G0-G1 phase; exhibited antiproliferative activity in a broad range of cell lines using monolayer and colony formation assays, reduces proliferation of hMECs in vitro and ADH/MIN lesions in vivo.Breast CancerPhase 2 Clinical

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