Novel selective procaspase-8 (Pro-C8) Inhibitor covalently binding the zymogen, or inactive precursor (pro-form), of caspase-8, but not other caspases

Potent inhibitor of tumor metastasis, inhibiting calmodulin, sialic acid, lipoperoxidation, fibrinogen, cell-movement and the cell-cycle arrest

Antagonist at the NR1/NR2A subtype but an agonist at the NR1/NR2D subtype

Novel reversible covalent selective LMP7 inhibitor

Novel, Reversible Covalent BTK Inhibitor for Rheumatoid Arthritis

Potent inhibitor of protein arginine methyltransferases (PRMTs)

Novel potent PRMT5 inhibitor, exhibiting potent anti-proliferative activity against a panel of leukemia and lymphoma cells

Novel potent and selective inhibitor of PRMT4 (also known as CARM1)

Potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3)

Allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)

Inducer of Functional Neurorestoration Via the Sigma-1 Receptor

Novel inhibitor of checkpoint kinase 1 (CHK1)

Inverse agonist at alpha-1 adrenergic receptors

Inhibitor of prostaglandin (PG) synthesis

Quorum sensing modulator as a PqsR antagonist

Novel human double minute 2 (HDM2) inhibitor

Novel inhibitor of IMPDH enzyme

Novel potent neuroprotectant, inhibiting glutamate-induced cell death, caspase-3 activation, and amyloid β1-42-induced cell death, also suppressing mitogen-activated protein kinase kinase 4 (MKK4) and c-jun N-terminal kinase (JNK) signaling activated by n

Specific blocker of the MARV VP40 PPxY-host Nedd4 interaction and subsequent PPxY-dependent egress of MARV VP40 VLPs.

Novel inhibitor of budding of mVP40 and eVP40 VLPs, blocking mVP40-795 Nedd4 protein-protein interaction.

Novel Modulator of Water-Heme Interactions in Low-Spin P450 Complexes of CYP2C9d and CYP125A1

Novel anti-influenza agent, interrupting the crucial RNP trafficking, resulting in influenza replication inhibition, preventing virus-induced cytopathic effects

Potent and selective antagonist of melanocortin-4 receptor (MC4R)

Novel PPK1 inhibitor, preventing UTI effectively through the disruption of the PPK1 function

Novel PPK1 inhibitor, preventing UTI effectively through the disruption of the PPK1 function

Novel pan-RAS-effector PPI inhibitor

Novel insulin mimetic

Novel inhibitor of protein-protein interaction (PPI), blocking #212121; font-family: BlinkMacSystemFont, -apple-system, "Segoe UI", Roboto, Oxygen, Ubuntu, Cantarell, "Fira Sans", "Droid Sans", "Helvetica Neue", sans-serif; font-size: 14px; font-style: no

Novel dual PPARα/γ agonist, ameliorating insulin resistance and gluconeogenesis in vivo and vitro

The first reported PPARα/δ dual antagonist