S9-A13|CAS 1223771-84-3|DC Chemicals

Cas No.:	1223771-84-3
Chemical Name:	1-(3-Chloro-4-methylphenyl)-3-methyl-4-[(5-methyl-2-thienyl)carbonyl]-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one
SMILES:	C1=C(C=CC(C)=C1Cl)N1N=C(C)C2=C1NC(CC2C(C1=CC=C(C)S1)=O)=O
Formula:	C₂₀H₁₈ClN₃O₂S
M.Wt:	399.89
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

S9-A13 is a highly potent and specific inhibitor of SLC26A9, potently inhibits SLC26A9-mediated Cl−/I− and Cl−/SCN− exchange activities with IC50 of 90.9 and 171.5 nM, respectively.S9-A13 does not inhibit other members of the SLC26 family and has no effects on Cl− channels such as CFTR, TMEM16A, or VRAC.S9-A13 (0-1 uM ) inhibits SLC26A9 currents in a dose-dependent manner in HEK293 cells, but shows little effects on CFTR currents in HEK293 cells at the highest concentration (5 uM).S9-A13 has a minor effect on ion transport in human airway epithelial cells and mouse trachea, despite clear expression of SLC26A9 in the apical membrane of ciliated cells.

MSDS

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