PZ09|PKC-zeta inhibitor 9|cas 1132609-87-0

Cas No.:	1132609-87-0
Chemical Name:	4-(3-(4-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)-1H-indazol-6-yl)aniline
Synonyms:	PZ09\|PKC-zeta inhibitor 9;PKC-ζ inhibitor PZ9
SMILES:	CN1CCN(C2C3NC(C4C5C(=CC(C6C=CC(N)=CC=6)=CC=5)NN=4)=NC=3C=CC=2)CC1
Formula:	C₂₅H₂₅N₇
M.Wt:	423.524
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Trujillo JI, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):908-11. 2. Kajimoto T, et al. Sci Signal. 2019 Jan 1;12(562). pii: eaat6662. doi: 10.1126/scisignal.aat6662.

Description:

PZ09 (PKC-zeta inhibitor 9, PKC-ζ inhibitor PZ9) is a potent, isoform selective PKC-zeta (PKC-ζ) inhibitor with IC50 of 5.18 nM, displays excellent selectivity (>200-fold) over other PKC isoforms with exception of PKC-i (10-fold). PZ09 also shows high selectivity for CDK-2 (>200-fold), as well as a broader range of other kinases (<50% inhibition at 10 uM). PZ09 is a small-molecule inhibitor, the first tool to successfully interrogate aPKC signaling in cells.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101
2018-0101
2018-0101

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PZ09(PKC-9)