Innate Defence Regulator Peptide, Enhancing Monocyte Migration and Adhesion on Fibronectin

Novel concentration dependent bactericidal agent against M. tuberculosis, being markedly more efficient at killing M. tuberculosis under acidic conditions

Novel bactericidal agent against M. tuberculosis under acidic conditions, being effective at sterilizing cultures in a concentration-dependent fashion at the highest concentrations

Selective ER modulator (SERM)

The first inhibitor targeting both IDO1/2 that has excellent in vitro inhibitory activity (IDO1 IC50 = 28 nM and IDO2 IC50 = 144 nM)

Novel mutant-selective Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor

Novel isocitrate dehydrogenase 2 (IDH2) mutants inhibitor for the treatment of cancer

Novel highly potent substrate-selective inhibitor of insulin-degrading enzyme (IDE), blocking insulin binding while allowing glucagon cleavage, even at saturating inhibitor concentrations

Novel highly potent substrate-selective inhibitor of insulin-degrading enzyme (IDE), blocking insulin binding while allowing glucagon cleavage, even at saturating inhibitor concentrations

M1 and M2 Antagonist

Novel μ,δ-Opioid Receptor Dual-Biased Agonist, Overcoming the Limitation of Prior Biased Agonist

Novel μ,δ-Opioid Receptor Dual-Biased Agonist, Overcoming the Limitation of Prior Biased Agonist

Novel μ,δ-Opioid Receptor Dual-Biased Agonist, Overcoming the Limitation of Prior Biased Agonist

Potent cytotoxin selectively by CYP1A1 as a tumor-selective treatment for human bladder cancers

DNA topoisomerase II inhibitor

Novel inhibitor of heat shock protein 90 (Hsp90), demonstrating anticancer activity against colorectal, osteosarcoma and cervical cancer cell lines

Novel highly selective, substrate-competitive SIRT2 inhibitor, displaying a significant neuroprotective effect in a lactacystin-induced model of Parkinsonian neuronal cell death in the N27 cell line

Novel potent and selective inhibitor of choline kinase alpha (CHKA)

Novel selective bacterial dihydrofolate inhibitor, antibiotic, actively against Gram positive organisms

Antimalarial agent, displaying blood schizonticidal activity against P.berghei

Potent thromboxane receptor antagonist

Novel selective inhibitor of CDK7

Novel inhibitor of CALP, exhibiting affinity of 22.6 ± 8.0 μM for CALP and no interaction with the NHERF PDZ domains

Inhibitor of voltage-gated K(+) (Kv) channels Kv1.3 and Kv1.5

Neuronal Kv7 potassium channel activator

MmpL3 inhibitor, being active against drug-resistant Mycobacterium tuberculosis

Novel HDAC6-selective inhibitor

Novel fluorescent irreversible inhibitor of Bruton's tyrosine kinase (BTK)

Novel Aurora kinase inhibitor, revealing mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Novel Aurora kinase inhibitor