First-in-class triple-acting PIM/PI3K/mTOR inhibitor, demonstrating single-agent, anti-tumour efficacy in suppression of pAKT, pmTOR and pBAD in the SKBR-3, BT-474 and HCC-1954 HER2+/PIK3CA-mutated cell lines

Novel activator of LFA-1-ICAM-1 binding

Novel inhibitor of the cluster of differentiation 14 innate immunity pathway

Novel antagonist of IAP (inhibitor of apoptosis protein)

Antibiotic enhancer against resistant Gram-negative bacteria

Antibiotic enhancer against resistant Gram-negative bacteria

Antibiotic enhancer against resistant Gram-negative bacteria

Selective kynurenine-3-hydroxylase inhibitor

Novel potent and selective inhibitor of human DNA polymerase kappa (hpol κ)

Novel potent and selective inhibitor of fat mass obesity-associated protein (FTO), being selectively over alkylation repair homologue 5 (ALKBH5), another DNA/RNA demethylase

Novel analogue of combretastatin A-4, enhancing connexin43 expression

Natural antagonist of serotonergic receptors and inhibitor of CDK5/p25 and GSK-3ß

Novel anticancer agent, inhibiting lung cancer cell proliferation via a PKCa and ERK1/2 dependent mechanism

Natural antioxidant and anti-cancer agent, blocking the MAPK/NF-κB and activating Nrf2/HO-1

Novel selective r(CGG)exp probe, improving pre-mRNA splicing defects, inhibiting formation of nuclear inclusions and RANT in a FXTAS cellular model

Novel potent and selective inhibitor of Schistosoma mansoni dihydroorotate dehydrogenase (SmDHODH)

Novel multitarget Fasudil derivative, inducing the NRF2 signature, promoting the expression of the antioxidant response enzymes HO-1 and NQO1, via a KEAP1-dependent mechanism

Activable Probe for Noninvasive Hydroxyl Radical Imaging, emitted in 1000-1400 nm after responding to ·OH

Inhibitor of apurinic endonuclease-1 (APE1) by direct protein binding

Novel CK2-Specific Pt(II) Compound, Reversing Cisplatin-Induced Resistance by Inhibiting Cancer Cell Stemness and Suppressing DNA Damage Repair in Non-small Cell Lung Cancer Treatments

Novel human antigen R (HuR) ligand, acting as a HuR-RNA interferer

Adhesive peptide (sequence 351-359 mapped on the Human Vitronectin Protein), covalent and selective functionalizing on glass and titanium surfaces, increasng osteoblast attachment and adhesion strength and to promoting osseointegration

Novel analgesic agent, activating TRPA1 and subsequently desensitizing the channel, exhibiting higher inhibitory activity than resveratrol

Novel activator of PC2

Novel, potent, selective, and orally efficacious dual antagonist of the orexin receptors

Novel allosteric antagonist of the glucagon-like peptide-1 receptor (GLP-1R)

Novel macrocyclic calcitonin gene-related peptide (CGRP) receptor antagonist

Novel macrocyclic calcitonin gene-related peptide (CGRP) receptor antagonist

Novel heat shock protein 90 (Hsp90), more potent enantiomer

Novel heat shock protein 90 (Hsp90) inhibitor