GW-8510| CAS 222036-17-1

Cas No.:	222036-17-1
Chemical Name:	Benzenesulfonamide,4-[[(6,7-dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]-N-2-pyridinyl-
Synonyms:	Benzenesulfonamide, 4-[[(6,7-dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]a mino]-N-2-pyridinyl-;Benzenesulfonamide,4-[[(6,7-dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]-N-2-pyridinyl-;GW8510;4-{[(7-Oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}-N-(2-pyridyl)benzenesulfonamide
SMILES:	O=C1NC2C=CC3=C(C=2/C/1=C/NC1C=CC(S(NC2C=CC=CN=2)(=O)=O)=CC=1)SC=N3
Formula:	C₂₁H₁₅N₅O₃S₂
M.Wt:	449.5055
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

GW-8510 (GW8510) is a potent, selective inhibitor of CDK2 with IC50 of 10 nM; displays weak inhibition for CDK1 and CDK4 (IC50=110 and 130 nM, respectively) in vitro biochemical assays; only inhibits CDK5 on cultured neurons; downregulates the expression of XIAP and no detectable effect on the expression of Bax, Bak, or Bcl2; also demonstrates neuroprotective ability in MN9D cells in the presence of 1-methyl-4-phenylpyridium (MPP(+)).

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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