1-Cyclohexyl-3-dodecyl urea | CDU

Cas No.:	402939-18-8
Synonyms:	CDU; N-Cyclohexyl-N-dodecyl urea; NCND
SMILES:	O=C(NC1CCCCC1)NCCCCCCCCCCCC
Formula:	C₁₉H₃₈N₂O
M.Wt:	310.52
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension[1].
Target:	IC50: soluble epoxide hydrolase (sEH)[1]
In Vivo:	1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) ( intraperitoneal injection; 3mg/day; 4 days) lowers systolic blood pressure by 30 mm Hg in Ang II hypertensive animals, whereas the corn oil vehicle has no effect on blood pressure in normotensive or Ang II hypertensive animals[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3mg/day Administration: Intraperitoneal injection; 4 days Result: Had antihypertensive properties.
References:	[1]. Imig JD,et al. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension.Hypertension. 2002 Feb;39(2 Pt 2):690-4.

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