ICI 198615|CAS 103202-59-1|DC Chemicals

Cas No.:	103202-59-1
Chemical Name:	ICI 198615
Formula:	C₁₂H₂₈O₂Si
M.Wt:	232.44
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC65211	KT-474	KT-474 is a highly active and selective, orally bioavailable IRAK4 degrader being developed for the treatment of toll-like receptor (TLR)/interleukin-1 receptor (IL-1R)-driven immune-inflammatory diseases.
DC80099	5-C-phenethyl-DNJ	5-C-phenethyl-DNJ is a selective α-glucosidase GAA inhibitor, with its Ki value for rhGAA being 0.81 μM. 5-C-phenethyl-DNJ exhibits extremely high selectivity for GANAB, GBA1, and GBA2. 5-C-phenethyl-DNJ can be used for the study of Pompe disease.
DC81060	ML161 analog 1	ML161 analog 1 (compound 38) is an analog of ML161. ML161 analog 1 is a selective allosteric inhibitor of PAR1 with an IC50 of 1.68 μM.
DC80080	4-Demethoxy-7,9-di-epi-daunorubicin	4-Demethoxy-7,9-di-epi-daunorubicin, a derivative of Daunorubicin, is an anthracycline antibiotics. 4-Demethoxy-7,9-di-epi-daunorubicin can bind to calf thymus DNA and forms a complex with the stacked DNA base pairs. 4-Demethoxy-7,9-di-epi-daunorubicin can inhibit prokaryotic nucleic acid polymerases, including E. coli DNA polymerase I and RNA polymerase. 4-Demethoxy-7,9-di-epi-daunorubicin can be used for researches of cancer and infection.
DC80071	3tBu-Crown TFA	3tBu-Crown TFA is a chelator. 3tBu-Crown TFA chelates radiometals and couples to biological targeting moieties to facilitate targeted delivery of chelated radiometals.3tBu-Crown TFA can be used for the research of cancer.
DC80023	2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid	2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid is a PROTAC linker that can be used in the synthesis of PROTACs.
DC80020	2-(4-Aminocyclohexyl)acetic acid	2-(4-Aminocyclohexyl)acetic acid is a PROTAC linker that can be used in the synthesis of PROTACs.
DC74523	XY-07-35	XY-07-35 is a potent, selective HDAC6 proteolysis targeting chimera (PROTAC) degrader with IC50 of 48.5 nM.
DC74514	SelDeg51	SelDeg51 (Selective Degrader of FKBP51) is a potent, selective FKBP51 PROTAC with Kd of 18 nM, Emax=90%.
DC74496	HJM-561	HJM-561 is a potent, selective and orally bioavailable EGFR PROTAC degrader, selectively degrades the EGFR C797S-containing triple mutants Del19/T790M/C797S and L858R/T790M/C797S with DC50 values of 9.2 nM and 5.8 nM, respectively.