AKR1C3 Inhibitor 5f|cas 1275482-57-9|DC Chemicals

Cas No.:	1275482-57-9
Chemical Name:	4-((2-methoxyphenyl)amino)benzoic acid
SMILES:	COC1C=CC=CC=1NC1C=CC(C(O)=O)=CC=1
Formula:	C₁₄NO₃H₁₃
M.Wt:	243.2579
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:

A cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) (IC50 = 2.65µM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 2.65µM, 84.4µM, for AKR1C3, AKR1C2, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 µM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells.

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