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AM 92016

  Cat. No.:  DC26176   Featured
Chemical Structure
133229-11-5
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More than 5000 active chemicals with high quality for research!
Field of application
A specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity. Exhibits proarrhythmic and prohypertensive activity in vivo.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 133229-11-5
Chemical Name: N-(4-(3-((3,4-dichlorophenethyl)(methyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide hydrochloride
Synonyms: AM-92016 HCl; AM 92016 HCl; AM92016 HCl; AM-92016 hydrochloride
SMILES: Cl.CN(CCC1=CC(Cl)=C(Cl)C=C1)CC(O)COC1=CC=C(NS(C)(=O)=O)C=C1
Formula: C19H25Cl3N2O4S
M.Wt: 483.829
Sotrage: 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
Description: AM 92016 (hydrochloride) is a specific IK inhibitor. AM 92016 (hydrochloride) delays rectifier potassium channel (IK), repolarizes the membrane thereby restricting the duration of the nerve impulse. AM 92016 (hydrochloride) prolongs cardiac action potential duration in guinea-pig and rabbit isolated ventricular cells with an IC50 of 30 nM[1].
References: [1]. ConnorsSP,etal.Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbitventricular cells. Br J Pharmacol. 1992 Aug;106(4):958-65.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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