APD668|CAS 832714-46-2|DC Chemicals

Cas No.:	832714-46-2
Chemical Name:	APD 668; APD-668
Synonyms:	APD 668; APD-668
SMILES:	O=C(OC(C)C)N(CC1)CCC1OC2=C3C(N(C4=CC=C(S(=O)(C)=O)C=C4F)N=C3)=NC=N2
Formula:	C₂₁H₂₄FN₅O₅S
M.Wt:	477.51

Description:

APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively.Chronic treatment withAPD668 showed for the first time that blood glucose and glycated hemoglobin (HbA1c) levels could be significantly reduced in Zucker Diabetic Fatty (ZDF) rats over several weeks of dosing. APD668 was the ?rst compound with thismechanism of action to be progressed into clinical development for the treatment of diabetes.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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