ARQ-621 |CAS 1095253-39-6|DC Chemicals

Cas No.:	1095253-39-6
Chemical Name:	N-(3-aminopropyl)-3-chloro-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylamino)-2-quinazolinyl]-3-butyn-1-yl]-2-fluoro-benzamide
Synonyms:	ARQ-621,ARQ621
SMILES:	O=C(N(CCCN)[C@@H](C(N1NC2=CC=CC=C2)=NC3=C(C=CC(Cl)=C3)C1=O)CC#C)C4=CC=CC(Cl)=C4F
Formula:	C₂₈H₂₄Cl₂FN₅O₂
M.Wt:	552.43
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ARQ 621 demonstrates anti-tumor activity against a wide range of human cancer cell lines in vitro, including colon, lung, endometrial, bladder, and hematologic cancer cell lines, with significantly less cytotoxicity against hematopoietic cells. ARQ 621, as a novel clinical stage drug candidate, inhibits a number of xenografts grown in athymic mice, such as pancreatic, breast, prostate, and ovarian carcinomas with no hematological changes. Furthermore, for ARQ 621, there is no envidence of bone marrow toxicity in pre-clinical mouse efficacy models or safety studies in rats and dogs. For the detailed information of ARQ 621, the solubility of ARQ 621 in water, the solubility of ARQ 621 in DMSO, the solubility of ARQ 621 in PBS buffer, the animal experiment (test) of ARQ 621, the cell expriment (test) of ARQ 621, the in vivo, in vitro and clinical trial test of ARQ 621, the EC50, IC50,and affinity,of ARQ 621, Please contact DC Chemicals.

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