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| Cas No.: | 1009298-59-2 |
| Chemical Name: | 3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide |
| Synonyms: | AZD 2014; AZD-2014 |
| SMILES: | O=C(NC)C1=CC=CC(C2=CC=C3C(N=C(N4[C@@H](C)COCC4)N=C3N5[C@@H](C)COCC5)=N2)=C1 |
| Formula: | C25H30N6O3 |
| M.Wt: | 462.54 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | AZD2014 is a close analogue of AZD8055 and a selective inhibitor of mTOR kinase. AZD2014 has greater inhibitory activity against mTORC1 compared to rapamycin: AZD2014 decreases p4EBP1 Thr37/46, inhibits the translation initiation complex and decreases overall protein synthesis while rapamycin has no effect. AZD2014 also inhibits the mTORC2 biomarkers pAKTSer473 and pNDRG1Thr346. AZD2014 has broad antiproliferative activity across multiple tumour cell lines. In particular, AZD2014 induces growth inhibition and cell death in breast cancer cell lines, including ER+ cell lines with acquired resistance to hormone therapy. AZD2014 induces tumour growth inhibition against several xenograft models including a human primary explant model of ER+ breast cancer refractory to tamoxifen. The antitumour activity is associated with modulation of both mTORC1 and mTORC2 substrates.For the detailed information of AZD2014, the solubility of AZD2014 in water, the solubility of AZD2014 in DMSO, the solubility of AZD2014 in PBS buffer, the animal experiment (test) of AZD2014, the cell expriment (test) of AZD2014, the in vivo, in vitro and clinical trial test of AZD2014, the EC50, IC50,and Affinity of AZD2014, Please contact DC Chemicals. |