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| Cas No.: | 251992-66-2 |
| Chemical Name: | Thieno[2,3-c]pyridine-2-carboxamide,4-[(4-methylphenyl)thio]- |
| Synonyms: | A205804,A 205804,A-205804 |
| SMILES: | O=C(N)C1=CC(C(SC2=CC=C(C)C=C2)=CN=C3)=C3S1 |
| Formula: | C15H12N2Os2 |
| M.Wt: | 300.4 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | A-205804 selectively inhibits the surface expression of the cell adhesion molecules ICAM-1 and E-selectin in human endothelial cells. A-205804 inhibites the IL-1β-induced expression of E-selectin (IC50 = 20 nM) and ICAM-1 (IC50 = 10 nM) with essentially the same level of potency as that For TNFα-induced expression. For reasons which are unclear, the ability of A-205804 to inhibit PMA-induced E-selectin expression is significantly reduced (IC50 > 1000 nM), but A-205804 is a potent inhibitor of ICAM-1 expression (IC50 = 40 nM) using this protein-kinase C-activating agent. For the detailed information of A-205804, the solubility of A-205804 in water, the solubility of A-205804 in DMSO, the solubility of A-205804 in PBS buffer, the animal experiment (test) of A-205804, the cell expriment (test) of A-205804, the in vivo, in vitro and clinical trial test of A-205804, the EC50, IC50,and Affinity of A-205804, Please contact DC Chemicals. |