A-317491 (sodium salt hydrate)|cas |DC Chemicals

Cas No.:	475205-49-3
Chemical Name:	A 317491;A317491;(S)-5-((3-phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1,2,4-tricarboxylic acid, sodium salt hydrate
Synonyms:	A 317491;A317491;(S)-5-((3-phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1,2,4-tricarboxylic acid, sodium salt hydrate
SMILES:	O=C(O)C1C(C(=O)O)=CC(C(=O)O)=C(C(=O)N([C@H]2C3C=CC=CC=3CCC2)CC2C=C(OC3C=CC=CC=3)C=CC=2)C=1.O.[Na+]
Formula:	C₃₃H₂₉NNaO₉+
M.Wt:	606.5739
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.It is known that P2X3 and P2X2/3 receptors stimulate the pronociceptive effects of ATP upon activation. Studies indicate that the P2X3 receptor is implicated in both neuropathic and inflammatory pain. P2X3 receptor is a promising target for therapeutic intervention in cancer patients for pain management.

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