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Aftin-4

  Cat. No.:  DC10844   Featured
Chemical Structure
866893-90-5
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More than 5000 active chemicals with high quality for research!
Field of application
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 866893-90-5
Chemical Name: Aftin-4
Synonyms: (2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol;Amyloid-β Forty-Two Inducer 4;N6-Methyl-(R)-roscovitine;Aftin-4;(2R)-2-({6-[BENZYL(METHYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)BUTAN-1-OL;R-2-[6-(Benzyl-methyl-amino)-9-isopropyl-9H-purin-2-ylamino]-butan-1-ol;Aftin 4;Aftin4;BDBM10909;BCP29117;DB04776;Q27095514;(R)-2-((6-(benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol;(2R)-2-({6-[benzyl(methyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)butan-1-ol;(2R)-2-({6-[benzyl(methyl)amino]-9-(1-methylethy;(2R)-2-[[6-[benzyl(methyl)amino]-9-propan-2-ylpurin-2-yl]amino]butan-1-ol;N6-METHYL-(R)-ROSCOVITINE, R-2-[6-(BENZYL-METHYL-AMINO)-9-ISOPROPYL-9H-PURIN-2-YLAMINO]-BUTAN-1-OL;(2R)-2-({6-[
SMILES: CC[C@@H](NC1=NC(N(CC2=CC=CC=C2)C)=C3N=CN(C(C)C)C3=N1)CO
Formula: C20H28N6O
M.Wt: 368.4759
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Aftin-4 is an Amyloid-β42 (Aβ42) inducer.
In Vivo: Aftin-4 increases Aβ1-42 levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD). Aftin-4 is administered at increasing doses, between 3 and 20 nmol/mouse, into the lateral ventricle and animals are sacrificed at various time points, between 3 to 14 days after injection. The hippocampus is dissected out the contents in Aβ1-40 or Aβ1-42 is determined using a mouse ELISA assay. Aftin-4 dose-dependently and significantly increases Aβ1-42 content, up to +216% at the highest dose tested[1].
In Vitro: Aftin-4 selectively and potently increases Aβ1-42 in N2a cells, primary neurons, and brain lysates, with an EC50 value around 30 μM[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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