Cas No.: | 216503-57-0 |
pH value: | Corresponds to reference standard: PASS |
Non-reduced CE-SDS: | 98.5% |
SEC-HPLC: | 99.4% |
Isoelectric Point: | Corresponds to reference standard |
Bacterial Endotoxins Test: | <1 EU/ml |
Exogenous Residual DNA: | <1 pg/mg |
Residual protein A: | <1 ng/mg |
Biological Activity: | Compared with standard, the range ofbiological activity is 91% |
Osmolality: | Corresponds to reference standard: PASS |
Peptide mapping: | Corresponds to reference standard: PASS |
N-terminal sequence: | Corresponds to reference standard:PASS |
Description: | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G). Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium containing neomycin. |