Atglistatin|cas 1469924-27-3|DC Chemicals

Cas No.:	1469924-27-3
Chemical Name:	Atglistatin
Synonyms:	Atglistatin;3-[4'-(Dimethylamino)-3-biphenylyl]-1,1-dimethylure;3-(4'-(Dimethylamino)-[1,1'-biphenyl]-3-yl)-1,1-dimethylurea;3-[4'-(Dimethylamino)-biphenyl-3-yl]-1,1-dimethylurea;AK175606;Atglistatin, >=98% (HPLC);AOB2795;AWOPBSAJHCUSAS-UHFFFAOYSA-N;HMS3744A05;HMS3653A18;BCP27988;s7364;2233AH;BDBM50185419;SY038696;BC600410;AB0279834;SW220102-1
SMILES:	O=C(N(C([H])([H])[H])C([H])([H])[H])N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1C([H])=C([H])C(=C([H])C=1[H])N(C([H])([H])[H])C([H])([H])[H]
Formula:	C₁₇H₂₁N₃O
M.Wt:	283.3681
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Atglistatin is a highly potent, selective and competitive inhibitor of adipose triglyceride lipase (ATGL) with an IC50 of ~0.7 μM For inhibition of lipolysis in vitro, but no toxicity up to a concentration of 50 μM. IC50 value: 0.7 uM Target: ATGL Atglistatin inactivated ATGL in the presence or absence of the ATGL co-activator CGI-58. It does not displace ATGL from lipid droplets of adipocytes. Immunoprecipitation experiments revealed that Atglistatin does not interfere with the interaction of ATGL and CGI-58. Atglistatin inhibited TG hydrolase activity of wild-type WAT in a dose-dependent manner up to 78% in animal models. It was highly effective in inhibiting lipolysis in WAT organ cultures of wild-type mice. Dose and time-dependent inhibition of lipolysis was also observed in fasted wild-type C57Bl/6J mice. Atglistatin can serve as a very useful tool compound to study the pathophysiology and druggability of ATGL in animal models of metabolic disease and cachexia .For the detailed information of Atglistatin, the solubility of Atglistatin in water, the solubility of Atglistatin in DMSO, the solubility of Atglistatin in PBS buffer, the animal experiment (test) of Atglistatin, the cell expriment (test) of Atglistatin, the in vivo, in vitro and clinical trial test of Atglistatin, the EC50, IC50,and Affinity of Atglistatin, Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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