BDTX-189|CAS 2414572-47-5|DC Chemicals

Cas No.:	2414572-47-5
Chemical Name:	BDTX-189
SMILES:	C=CC(NC1=CC2=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)N=CN=C2C=C1OCCN5CCOCC5)=O
Formula:	C₂₉H₂₉ClN₆O₄
M.Wt:	561.03
Purity:	>98%
Sotrage:	Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months-20°C1 month
Publication:	[1]. Elizabeth Buck, et al. BDTX-189, a Potent and Selective Inhibitor of Allosteric EGFR and HER2 Oncogenic Mutations.

Description:

BDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, includes EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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