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Home > Inhibitors & Agonists > Epigenetics > HDAC

BRD73954

  Cat. No.:  DC7936   Featured
Chemical Structure
1440209-96-0
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More than 5000 active chemicals with high quality for research!
Field of application
BRD-73954 is a biochemical inhibitor histone deacetylase cancer histone modification epigenetics gene regulation small molecule HDAC6 HDAC8.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1440209-96-0
Chemical Name: 3-N-Hydroxy-1-N-(2-phenylethyl)benzene-1,3-dicarboxamide
Synonyms: BRD73954;BRD-73954;N-Hydroxy-N′-phenethyl-isophthalamide;N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide;N1-Hydroxy-N3-phenethylisophthalamide;BRD 73954;AOB4639;BCP12818;s7726;BDBM50434126;BC600649;AK546304;BRD73954, >=98% (HPLC);B4988;N1-hydroxy-N3-(2-phenylethyl)benzene-1,3-dicarboxamide;3-N-hydroxy-1-N-(2-phenylethyl)benzene-1,3-dicarboxamide;BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-di
SMILES: O=C(C1C([H])=C([H])C([H])=C(C(N([H])O[H])=O)C=1[H])N([H])C([H])([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H]
Formula: C16H16N2O3
M.Wt: 284.3098
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
References: [1]. Olson DE, et al. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013 Jun 13;56(11):4816-4820.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC70802 SS-208 SS-208 (SS208) is a novel potent, selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 12 nM, >100-fold selectivity over HDAC1/4/5/7/8/9/11.SS-208 has minimal effects on the viability of murine SM1 melanoma cells in vitro, significantly reduced in vivo tumor growth in a murine SM1 syngeneic melanoma mouse model.
DC3110 CUDC-907 (PI3K/HDAC InhibitorI) CUDC-907 (PI3K/HDAC Inhibitor I) is a dual PI3K and HDAC inhibitor for PI3Kɑ, HDAC1, HDAC2, HDAC3 and HDAC10 with IC50 of 19 nM, 1.7 nM, 5 nM, 1.8 nM and 2.8 nM, respectively.
DC8252 Vorinostat (SAHA) Vorinostat (SAHA) is an HDAC1/3 inhibitor with IC50 of ~10 nM.
DC8663 UF010 UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.
DC6303 Tubastatin A HCl Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
DC6304 Tubastatin A Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
DC5178 Tubacin (BML-GR362) Tubacin is a selective inhibitor of HDAC6 via inhibition of the second deacetylase domain (DD2).
DC8134 Trichostatin A (TSA) Trichostatin A (TSA) is a selective and potent HDAC inhibitor with IC50 of ~1.8 nM; HDAC8 is the only known member of the HDAC-family that is not affected by TSA.
DC7716 TMP269 TMP269 is a novel and selective class IIa histone deacetylase inhibitor with IC50s of 126/80/36/9 nM for HDAC 4/5/7/9, respectively; 20-400 fold selectivity over class1 HDACs.
DC10210 TMP195 TMP195 is the most potent and selective class IIa HDAC inhibitor.
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