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Brevetoxin B

  Cat. No.:  DC40337  
Chemical Structure
79580-28-2
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More than 5000 active chemicals with high quality for research!
Field of application
Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 79580-28-2
Chemical Name: Brevetoxin B
SMILES: C[C@@]1(O[C@](C)(CC[C@@](O[C@@](C[C@](C)(O[C@@](C(C)=CC2=O)([H])[C@](O2)([H])C3)[C@]3([H])O4)([H])[C@]4([H])C5)([H])[C@]([C@@H]5C)([H])O6)[C@]6([H])C7)[C@]7([H])O[C@]8(C)[C@@](O[C@](C[C@](O[C@@](C)([C@H]9O)[C@@](O[C@H](CC(C=O)=C)C9)([H])C%10)([H])[C@@]%10
Formula: C50H70O14
M.Wt: 895.08
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
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MSDS_23350_DC40337_79580-28-2
COA
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Cat. No. Product name Field of application
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DC45807 Nav1.7-IN-8 Nav1.7-IN-8 is a potent blockage of NaV1.7 with high selectivity for the inhibition of NaV1.7 over the subtypes hNaV1.1 and hNaV1.5. Nav1.7-IN-8 inhibits CYP2C9 and CYP3A4 with an IC50 of 0.17 μM and 0.077 μM, respectively. Nav1.7-IN-8 displays significant analgesic effects in rodent models of acute and inflammatory pain.
DC45806 GDC-0310 GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, with an IC50 of 0.6 nM for hNav1.7.
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