COL-144 succinate|CAS 439239-92-6|DC Chemicals

Cas No.:	439239-92-6
Chemical Name:	Lasmiditan hemisuccinate
Synonyms:	butanedioic acid,2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide;LASMIDITAN SUCCINATE;Lasmiditan hemisuccinate;W64YBJ346B;LY683974;2,4,6-Trifluoro-N-(6-((1-methylpiperidine-4-yl)carbonyl)pyridin-2-yl)benzamide succinic (2:1);Lasmiditan succinate [USAN];Reyvow (TN);Lasmiditan succinate (JAN/USAN);s6489;D10424;Q27292373;2,4,6-Trifluoro-N-(6-((1-methylpiperidine-4-yl)carbonyl)pyridin-2-yl)benzamide hemisuccinate;Butanedioic acid, compd. with 2,4,6-trifluoro-N-(6-((
SMILES:	FC1C=C(C=C(C=1C(NC1=CC=CC(C(C2CCN(C)CC2)=O)=N1)=O)F)F.FC1C=C(C=C(C=1C(NC1=CC=CC(C(C2CCN(C)CC2)=O)=N1)=O)F)F.OC(CCC(=O)O)=O
Formula:	C₄₂H₄₂F₆N₆O₈
M.Wt:	872.808711528778
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo.

MSDS

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MSDS_14705_DC32393_439239-92-6

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COL-144 (Lasmiditan) succinate