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Cinobufagin (Cinobufagine)

  Cat. No.:  DC50006   Featured
Chemical Structure
470-37-1
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More than 5000 active chemicals with high quality for research!
Field of application
Cinobufagin, a kind of Chinese materia medica with antitumor effect, is widely used in clinical practice, especially in anti-liver cancer. IC50 value: Target: In vitro: Cinobufagin inhibited proliferation of cancer cells at doses of 0.1, 1, or 10 μM after 2–4 days of culture. Cytotoxicity of cinobufagin on the DU145 and LNCaP cells was dose-dependent. Cinobufagin increased [Ca2+]i and apoptosis in cancer cells after a 24-hr culture as well as caspase 3 activities in DU145 and PC3 cells and caspase 9 activities in LNCaP cells [1]. Cinobufagin suppresses cell proliferation and causees apoptosis in prostate cancer cells via a sequence of apoptotic modulators, including Bax, cytochrome c and caspases [2].
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 470-37-1
Chemical Name: Cinobufagin (Cinobufagine)
Synonyms: Cinobufagin (Synonyms: Cinobufagine
SMILES: C[C@]([C@H]1C(C=C2)=COC2=O)(CC3)[C@]([C@@]4([H])[C@@]3([H])[C@](CC[C@H](O)C5)(C)[C@]5([H])CC4)(O6)[C@H]6[C@@H]1OC(C)=O
Formula: C26H34O6
M.Wt: 442.55
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DCY-155 Eupalinolide B >98%,Standard References
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