Cisatracurium (besylate)

Cas No.:	96946-42-8
Chemical Name:	Cisatracurium besilate
Synonyms:	(1r,1'r,2r,2'r)-2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium dibenzenesulfonate;cisatracurium besilate;cisatracurium besylate;1R-CIS,1R∧-CIS (CISATRACURIUM BESYLATE);Cisatracurium;Cisatrcurium Besylate;3-[(1R,2R)-6,7-dimethoxy-2-methyl-1-veratryl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propionic acid 5-[3-[(1R,2R)-6,7-dimethoxy-2-methyl-1-veratryl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl ester;5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
SMILES:	C[N@@+]1(CCC(OCCCCCOC(CC[N@@+]2([C@H](CC3=CC=C(OC)C(OC)=C3)C3C(=CC(=C(OC)C=3)OC)CC2)C)=O)=O)[C@H](CC2=CC=C(OC)C(OC)=C2)C2C(=CC(=C(OC)C=2)OC)CC1.[O-]S(C1=CC=CC=C1)(=O)=O.[O-]S(C1=CC=CC=C1)(=O)=O
Formula:	C53H72N2O12.2(C6H5O3S);
M.Wt:	1243.48
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission. Cisatracurium is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is a bisbenzyltetrahydroisoquinolinium agent with an intermediate duration of action. Cisatracurium is one of the ten isomers of the parent molecule, atracurium. Moreover, cisatracurium represents approximately 15% of the atracurium mixture.
Target:	AChR
References:	[1]. Dear, G.J., et al., Identification of urinary and biliary conjugated metabolites of the neuromuscular blocker 51W89 by liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom, 1995. 9(14): p. 1457-64. [2]. Serra, C.S. and A.C. Oliveira, Cisatracurium: myographical and electrophysiological studies in the isolated rat muscle. Fundam Clin Pharmacol, 2006. 20(3): p. 291-8.