Cordycepin|cas 73-03-0|DC Chemicals

Cas No.:	73-03-0
Chemical Name:	Cordycepin
Synonyms:	Cordycepin;3'-DEOXYADENOSINE;3’-deoxy-adenosin;9-cordyceposidoadenine;cordycepin crystalline;9-(3-Deoxy-b-D-erythro-pentofuranosyl)-9H-purin-6-amine;9-(3-Deoxy-b-D-ribofuranosyl)adenine;Cordycepin from Cordyceps militaris;CORDYCEPIN(RG);(-)-cordycepin;3'-Deoxy-D-adenosine;Adenine cordyceposide;Adenosine,3-deoxy;Cordycepin Hydrate;Cordyceps fungus powder;3'-Deoxyadenosine from Cordyceps militaris;3′-Deoxyadenosine;Cordycepine;ADENOSINE, 3'-DEOXY-;9-(beta-D-3'-Deoxyribofuranosyl)adenine;9H-Purine, 6-amino-9-(3-deoxy-beta-D-ribofuranosyl)-;GZ8VF4M2J8;OFEZSBMBBKLLBJ-BAJZRUMYSA-N;beta-D-erythro-Pentofuranoside, adenine-9 3-deoxy-;9H-Purin-6-amine, 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-;(2R,3R,5S)-2-(6-amino-9H-purin-9-yl)-5-(hydroxy
SMILES:	O1[C@]([H])(C([H])([H])O[H])C([H])([H])[C@]([H])([C@]1([H])N1C([H])=NC2=C(N([H])[H])N=C([H])N=C12)O[H]
Formula:	C₁₀H₁₃N₅O₃
M.Wt:	251.2419
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Cordycepin, which is a nucleoside derivative isolated from Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner.

In Vitro:

Cordycepin is a potent inhibitor of IL-1β-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs. The effect of Cordycepin on cellular toxicity of RASFs is assessed using MTT assay. Treatment of RASFs with Cordycepin (50 μM or 100 μM) for 24 h does not cause any significant change in cell viability. However, cell viability is slightly decreased when cells are incubated with 100 μM Cordycepin for 48 h[1].

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