Cyclosporin A|cas 59865-13-3|DC Chemicals

Cas No.:	59865-13-3
Chemical Name:	Cyclosporin A
Synonyms:	Cyclosporin A;Cyclosporin A (Cyclosporine ,Antibiotic S 7481F1,Ciclosporin A, Ramihyphin A,CsA);Cyclosporin A solution;CYCLOSPORIN A, TOLYPOCLADIUM INFLATUM;Cyclosporine;Cyclosporine A;Atopica;ciclosporin;ciclosporin A;Cipol N;Cyclosporin A from Tolypocladium inflatum;Cyclosporine Resolution Mixture;Neoplanta;Neoral;ol27-400;Optimmune;Restasis;s7481f1;sandimmun;sandimmun neoral;Sandimmun optoral;Cyclosporin;Antibiotic S 7481F1;Ciclosporine;Ciclosporinum;Ciclosporina;Sandimmune;Equoral;Gengraf;Consupren;Ramihyphin A;SangCyA;83HN0GTJ6D;MLS001333756;CSA;S-Neoral;Sigmasporin Microoral;Sang 35;DSSTox_CID_365;Ciclosporinum [INN-Latin];Ciclosporine [INN-French];Ciclosporina [INN-Spanish];DSSTox_RID_75541;Ciclosporin (Ciclo
SMILES:	O([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])/C(/[H])=C(\[H])/C([H])([H])[H])[C@@]1([H])C(N([H])[C@]([H])(C(N(C([H])([H])[H])C([H])([H])C(N(C([H])([H])[H])[C@]([H])(C(N([H])[C@]([H])(C(N(C([H])([H])[H])[C@]([H])(C(N([H])[C@@]([H])(C([H])([H])[H])C(
Formula:	C₆₂H₁₁₁N₁₁O₁₂
M.Wt:	1202.6113
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Cyclosporin A is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM.
In Vivo:	Cyclosporin A has immunosuppressive activity, and is active via parenteral and p.o. administration in mice, rat and guinea pigs[6]. Cyclosporin A can be used in organ transplantation to prevent rejection[7].
In Vitro:	Cyclosporin A is able to bind with the cyclophilin in T cells[1]. Cyclosporin A works by forming a Cyclophilin-Cyclosporin A complex to inhibit calcineurin[2]. Cyclosporin A exhibits inhibitory effect on calcineurin with an IC50 of 7 nM[3]. Cyclosporin A suppresses the nuclear translocation of NF-AT[4]. Cyclosporin A shows an effect on mitochondria via preventing the MTP from opening with an IC50 of 39 nM[5].