TLR7 and 8 modulator 31|

Cas No.:	1413944-59-8
Chemical Name:	(S)-3-((2-Amino-8-fluoroquinazolin-4-yl)amino)hexan-1-ol
SMILES:	C(O)C[C@H](NC1=C2C(=NC(N)=N1)C(F)=CC=C2)CCC
Formula:	C₁₄H₁₉FN₄O
M.Wt:	278.331
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

TLR7 and 8 modulator 31 is a potent, orally active, dual TLR7 and 8 agonist with LEC values of 0.15 and 0.16 uM, respectively; displays a good off-target profile (Aa1A, D1, 5HT2A IC50>10 µM; CYP 2D6 IC50=5.7 µM), also shows no significant activity against a panel of 80 receptors; induces IFNα and pro-inflammatory cytokines at low dose in vivo, inhibits HBV replication indirectly, via cytokine induction and immune cells activation; induces endogenous IFNα, an interferon stimulated gene response (ISGs), and also activation of myeloid dendritic cells and monocytes towards a TH1 phenotype in both mice and cynomolgus monkeys in vivo.

Cat. No.	Product name	Field of application
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