AD-35 hydrochloride|AD35 hydrochloride;AD 35 hydrochloride

Cas No.:	1531586-62-5
Chemical Name:	6'-(2-(1-(pyridin-2-ylmethyl)piperidin-4-yl)ethyl)spiro[cyclopropane-1,5'-[1,3]dioxolo[4,5-f]isoindol]-7'(6'H)-one hydrochloride
Synonyms:	AD35 hydrochloride;AD 35 hydrochloride
Formula:	C₂₄H₂₈ClN₃O₃
M.Wt:	441.956
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
DC47776	Millmerranone A	Millmerranone A shows the acetylcholinesterase inhibitory property.
DC47775	Chikusetsusaponin Ib	Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent AChE inhibitor.
DC47774	Cyclopenin	Cyclopenin ((±)-Isocyclopenine) is a racemate.
DC47773	Cyclanoline chloride	Cyclanoline (chloride) shows cholinesterase inhibitory activity.
DC47772	Isonaringin	Isonaringin shows anti-Alzheimer’s activity by inhibiting AChE.
DC47239	Zanapezil free base	Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD).
DC46568	Acotiamide D6	Acotiamide D6 is a deuterium labeled Acotiamide. Acotiamide is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia.
DC46069	Echimidine N-oxide	Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC50=0.347 mM).
DC45995	Manghaslin	Manghaslin is a flavonoid glycoside with anti-inflammatory activities. Manghaslin shows inhibitory activity against AChE with an IC50 of 94.92 µM.
DC44782	O-Desmethyl Galanthamine	O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.