Cas No.: | 2058116-54-2 |
Chemical Name: | 1-(5-amino-2,3-dihydro-1H-inden-2-yl)-3-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
Synonyms: | MDVN1003;MDVN 1003 |
SMILES: | C1=NC(N)=C2C(C3=CC(F)=C4C(=C3)NCCO4)=NN(C3CC4=C(C3)C=CC(N)=C4)C2=N1 |
Formula: | C22H20FN7O |
M.Wt: | 417.45 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A first-in-class, selective, orally bioavailable, dual inhibitor of BTK and PI3Kδ kinases with IC50 of 32.3 nM and 16.9 nM, respectively; inhibits B cell activation upon BCR cross-linking ex vivo and in vivo, induces apoptosis and decreases viability of DOHH-2 cells; shows significant anti-tumor effects in an NHL xenograft model in mice. |