Calmidazolium chloride ( R 24571)|Cas 57265-65-3|DC Chemicals

Cas No.:	57265-65-3
Chemical Name:	1H-Imidazolium,3-[bis(4-chlorophenyl)methyl]-1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-,chloride (1:1)
Synonyms:	R 24571
SMILES:	[Cl-].ClC1C=CC(COC(C2C=CC(Cl)=CC=2Cl)C[N+]2C=CN(C(C3C=CC(Cl)=CC=3)C3C=CC(Cl)=CC=3)C=2)=C(Cl)C=1
Formula:	C₃₁H₂₃Cl₇N₂O
M.Wt:	687.7
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively[1]. Also in anti-cancer research[2]. Calmidazolium binds to CaMK with a Kd of 3 nM.
Target:	Kd: 3 nM (Calmodulin)[3]
In Vitro:	Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs[2]. Cell Viability Assay[2] Cell Line: Mouse F9 ECCs Concentration: 3, 5, 7, 10 μM Incubation Time: 30 minutes-24 hours Result: The IC50s of Calmidazolium chloride treated F9 ECCs and E14 ESCs are 8.18 μM, and 12.69 μM[2].
References:	[1]. Gietzen K, et al. Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem J. 1983 Dec 15;216(3):611-6. [2]. Lee J, et al. Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. Toxicol In Vitro. 2016 Sep;35:86-92. [3]. Budu A, et al. Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum. Cell Signal. 2016 Mar;28(3):125-135.

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Calmidazolium chloride (R 24571)