TP0463518|CAS 1558021-37-6|PHDs inhibitor|DC Chemicals

Cas No.:	1558021-37-6
Chemical Name:	TP0463518;TP-0463518;TP 0463518
Synonyms:	TP0463518;TP-0463518;TP 0463518
SMILES:	ClC1=CC=C(OC2C=CC(CN3CCC(O)=C(C(=O)NCC(=O)O)C3=O)=CN=2)C=C1
Formula:	C₂₀H₁₈ClN₃O₆
M.Wt:	431.826424121857
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	ences [1]. Kato S, et al. TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation. Eur J Pharmacol. 2018 Nov 5;838:138-144.

Description:

TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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