GGsTop (Synonyms: Nahlsgen)|CAS 926281-37-0

Cas No.:	926281-37-0
Chemical Name:	GGsTop
Synonyms:	GGSTOPTM;GGsTop
SMILES:	O=C(O)CC1=CC=CC(OP(OC)(CCC(N)C(O)=O)=O)=C1
Formula:	C₁₃H₁₈NO₇P
M.Wt:	331.25832
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

In Vitro GGsTop (Nahlsgen; Compound 5a) is a potent, highly selective and irreversible γ−glutamyl transpeptidase (GGT) inhibitor, with a Ki of 170 μM for Human GGT[1]. GGsTop shows pKa of 9.71, also exhibits Kons of 150±10 and 51±3 M-1 s-1 against E.coli GGT and human GGT, respectively. GGsTop is non-toxic compound, completely inhibits WT human GGT in 1 min at 1 mM, but less potent against the K562S mutant. In Vivo GGsTop (1 mg/kg) lowers levels of ALT, AST, γ-GT at 12, 24, and 48 h after ischemia-reperfusion in rats. GGsTop also reduces 4-HNE and TNF-α production, and decreases hepatic necrosis in rats.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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GGsTop (Nahlsgen)