CB-6644

Cas No.:	2316817-88-4
Chemical Name:	CID 137333455
Synonyms:	5-Chloro-2-ethoxy-4-fluoro-N-[4-[[3-(methoxymethyl)-1-oxo-6,7-dihydro-5H-pyrazolo[1,2-a][1,2]benzodi;5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-oxobutyl)benzamide;BCP31705;CB 6644;CB6644;CB-6644;oxobutyl)benzamide;oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-;a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-;5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-;5-chloro-2-ethoxy-4-fluoro-N-[4-[[3-(methoxymethyl)-1-oxo-6,7-dihydro-5H-pyrazolo[1,2-a][1,2]benzodiazepin-2-yl]amino]-2,2-dimethyl-4-oxobutyl]benzamide;CID 137333455
SMILES:	ClC1=C(C([H])=C(C(=C1[H])C(N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(N([H])C1C(N2C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C([H])([H])N2C=1C([H])([H])OC([H])([H])[H])=O)=O)=O)OC([H])([H])C([H])([H])[H])F
Formula:	C₂₉H₃₄ClFN₄O₅
M.Wt:	573.0555
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

In Vitro CB-6644 (20 µM) interacts with the RUVBL1/2 complex in Ramos cells. CB-6644 (0.4 µM, 80 hours) dramatically inhibits HCT116 cells growth rate and robustly induces apoptosis. Z-VAD-FMK alone does not influence the growth or viability of the cells. However, blockade of caspase activity by Z-VAD-FMK results in a partial recovery of the growth of cells treated with CB-6644. In Vivo CB-6644 (150 mg/kg, oral administration, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models, 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models) has antitumor activity in xenograft tumor models with tumor growth inhibitions (TGIs) of 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.

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