Delafloxacin meglumine (Synonyms: ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine)

Cas No.:	352458-37-8
SMILES:	CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.FC1=CC(F)=C(N2C=C(C(=O)O)C(=O)C3=CC(=C(C(Cl)=C23)N2CC(O)C2)F)N=C1N
Formula:	C₂₅H₂₉ClF₃N₅O₉
M.Wt:	635.97
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Delafloxacin meglumine is a fluoroquinolone antibiotic agent.ABT-492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonfermentative, gram-negative organisms.
Target:	IC50 Value: MICs ranging from 0.0078 to 0.125 micro g/ml for levofloxacin-resistant Streptococcus pneumoniae strains [1] Target: Antibacterial
In Vitro:	ABT-492 exhibited excellent in vitro activities against all 326 aerobic and anaerobic antral puncture sinus isolates tested with MICs (in micrograms per milliliter) at which 90% of the isolates tested were inhibited as follows: Haemophilus influenzae, 0.001; Moraxella catarrhalis, 0.008; and Streptococcus pneumoniae, 0.015 [2]. ABT-492 was as active as trovafloxacin against Chlamydia trachomatis, indicating good intracellular penetration and antibacterial activity [3].
References:	[1]. Gunderson SM, Hayes RA, Quinn JP, In vitro pharmacodynamic activities of ABT-492, a novel quinolone, compared to those of levofloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Antimicrob Agents Chemother. 2004 Jan;48(1):203-8. [2]. Goldstein EJ, Citron DM, Merriam CV, In vitro activities of ABT-492, a new fluoroquinolone, against 155 aerobic and 171 anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis. Antimicrob Agents Chemother. 2003 Sep;47(9):3008-11. [3]. Nilius AM, Shen LL, Hensey-Rudloff D, In vitro antibacterial potency and spectrum of ABT-492, a new fluoroquinolone. Antimicrob Agents Chemother. 2003 Oct;47(10):3260-9.

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Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine)