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T-26c

  Cat. No.:  DC20124   Featured
Chemical Structure
869296-13-9
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More than 5000 active chemicals with high quality for research!
Field of application
T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 869296-13-9
SMILES: COC1=CC=CC(=C1)CNC(=O)C2=NC3=C(C(=CS3)COCC4=CC=C(C=C4)C(=O)O)C(=O)N2
Formula: C24H21N3O6S
M.Wt: 479.51
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1].
Target: IC50: 6.75 pM (MMP-13)[1]
In Vitro: T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage[1].
References: [1]. Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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