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6-Hydroxy-DL-DOPA

  Cat. No.:  DC20297   Featured
Chemical Structure
21373-30-8
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More than 5000 active chemicals with high quality for research!
Field of application
6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 21373-30-8
Chemical Name: Tyrosine,2,5-dihydroxy-
Synonyms: Tyrosine,2,5-dihydroxy-
SMILES: OC(C(CC1=CC(O)=C(O)C=C1O)N)=O
Formula: C9H11NO5
M.Wt: 213.187342882156
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: 6-Hydroxy-DOPA is a selective and effective allosteric inhibitor of the RAD52 ssDNA binding domain. 6-Hydroxy-DOPA can be used for the research of cancer[1].
Target: RAD52[1]
In Vitro: 6-Hydroxy-DOPA (0~20 μM; U20S cells) selectively inhibits RAD52-mediated recombination. 6-Hydroxy-DOPA (0~10 μM; HEK293T cells) decreases the number of eGFP-RAD52 foci in a dose-dependent manner. 6-Hydroxy-DOPA (5~75 μM; HCC1937 cells) selectively reduces the viability of the BRCA1-deficient triple-negative breast cancer cell line HCC1937[1].
References: [1]. Chandramouly G, et al. Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem Biol. 2015;22(11):1491-1504.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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