AI-10-104 |CAS 1881276-00-1|DC Chemicals

Cas No.:	1881276-00-1
Chemical Name:	AI-10-104
SMILES:	O(C(F)(F)F)C1C=CC2=C(C=1)N=C(C1N=CC=CC=1OC)N2
Formula:	C₁₄H₁₀F₃N₃O₂
M.Wt:	309.243313312531
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays; reduces RUNX transcriptional activity by interfering with the formation of the CBFβ/RUNX1 and/or CBFβ/RUNX3 heterodimers in T-ALL cells; impairs the growth of human T-ALL cell lines and primary patient samples (GI50=2.4 uM).

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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