Hydrazinocurcumin|CAS 131068-23-0|DC Chemicals

Cas No.:	131068-23-0
Chemical Name:	4,4'-((1E,1'E)-(1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol)
SMILES:	N1=C(/C=C/C2=CC=C(O)C(OC)=C2)C=C(/C=C/C2C=CC(O)=C(OC)C=2)N1
Formula:	C₂₁H₂₀N₂O₄
M.Wt:	364.401
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Shim JS, et al. Bioorg Med Chem. 2002 Sep;10(9):2987-92. 2. Shim JS, et al. Bioorg Med Chem. 2002 Aug;10(8):2439-44. 3. Wang X, et al. Int J Oncol. 2012 Apr;40(4):1189-95.

Description:

Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets; suppresses cell proliferation, depresses cell migration and invasion, induces cell apoptosis; inhibits the cell cycle progression of colon cancer cells via antagonizing of Ca2+/calmodulin functions.

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