STOML3 inhibitor OB-1|CAS 300803-69-4|DC Chemicals

Cas No.:	300803-69-4
Chemical Name:	ethyl 5-((1-methyl-4-nitro-1H-imidazol-5-yl)oxy)-2-phenylbenzofuran-3-carboxylate
Synonyms:	OB-1;OB1;OB 1
SMILES:	C(OC(C1C2C=C(OC3N(C)C=NC=3[N+]([O-])=O)C=CC=2OC=1C1C=CC=CC=1)=O)C
Formula:	C₂₁H₁₇N₃O₆
M.Wt:	407.382
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Wetzel C, et al. Nat Neurosci. 2017 Feb;20(2):209-218.

Description:

A small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo; effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin; reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo; also reversibly attenuates fine touch perception in normal mice, reverses pathological mechanical hypersensitivity.

MSDS

COA

LOT NO.	DOWNLOAD
2018-0101

2018-0101
2018-0101

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