Cas No.: | 577779-57-8 |
Chemical Name: | 4,5,6,7-Tetrabromobenzimidazole |
Synonyms: | 4,5,6,7-Tetrabromobenzimidazole;4,5,6,7-tetrabromo-1H-benzimidazole;4,5,6,7-Tetrabromobe;tbbz;2oxy;4,5,6,7-Tetrabrom-1H-benzimidazol |
SMILES: | BrC1C2=C(N=CN2)C(Br)=C(Br)C=1Br |
Formula: | C7H2Br4N2 |
M.Wt: | 433.720178127289 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | A potent, selective and ATP-competitive CK2 inhibitor with Ki of 0.5-1 uM; weakly inhibits CK1 (about 100-fold less potent), and has no activity for PKA and PKC; decreases the activity of GBM-initiating cell regulator β-catenin, reduces cell growth, decreases tumor size, and increases survival rates in GBM xenograft mouse models. |